Cardiometabolic Management Essentials for Advanced Practice Providers (APPs)-Advanced Lipid Management

Video Transcription

Video Summary

In this video, the speaker discusses advanced lipid management with a focus on hypercholesterolemia classification. The primary causes of hypercholesterolemia include genetic and idiopathic factors. The speaker emphasizes the importance of ruling out secondary causes of elevated LDL cholesterol levels. The diagnosis of primary hypercholesterolemia is made when LDL cholesterol levels are greater than or equal to 130 or non-HDL cholesterol levels are greater than or equal to 160, in addition to having a definitive genetic study or meeting specific criteria. The most common genetic cause of hypercholesterolemia is familial hypercholesterolemia (FH), which can be heterozygous or homozygous. The speaker stresses the importance of early diagnosis and treatment of FH, as it significantly increases cardiovascular risk. Cascade screening is recommended for first-degree relatives of patients with FH. Other genetic lipid disorders discussed include dys-beta-lipoproteinemia, lysosomal acid lipase deficiency, familial combined hyperlipidemia, and familial chylomicronemia syndrome. The speaker also highlights the role of lipoprotein A (Lp(a)) in increasing cardiovascular risk, especially in combination with other risk factors. The treatment of hypertriglyceridemia involves lifestyle modifications, medication, and addressing secondary factors. The speaker mentions the use of fibrates and omega-3 fatty acids in severe cases. The video concludes by emphasizing the importance of individualized treatment and considering a referral to a lipid specialist for further evaluation and management.

Keywords

advanced lipid management

hypercholesterolemia classification

genetic factors

idiopathic factors

primary hypercholesterolemia diagnosis

familial hypercholesterolemia

cascade screening

genetic lipid disorders

hypertriglyceridemia treatment